Neurodegenerative diseases are a group of disorders that are characterised by the progressive loss of structure respective function of neurons, including their death. The most known disorders include Alzheimer’s Disease, Parkinson’s disease, Multiple Sclerosis and Amyotrophic Lateral Sclerosis (ALS), but as research in this field increases, more diseases are shown to have similar cellular and sub-cellular pathogenic mechanisms.
Oxford Biosystems offers a range of products to detect and measure neurodegeneration biomarkers in both cerebrospinal fluid and blood samples.
IBL International GmbH, part of the Tecan Group, have wide range of ELISA products for research in the field of neurodegeneration:
- Amyloid-beta and TAU protein detection in CSF to support research of Alzheimer’s disease
- Neurofilament – Light (NF-Light) kits for use with CSF and serum samples. Neurofilaments are the backbone of the neuronal cytoskeleton and are elevated in neurodegenerative disorders associated with the destruction of white matter (substantia alba), typically Parkinson’s disease, Multiple sclerosis and ALS.
- α-Synuclein is a protein predominantly localized in the presynaptic terminals and is involved in vesicle fusion and neurotransmitter release. Tecan offers the hSYN ELISA, provided by Roboscreen, for the detection of total human α-Synuclein, and the α-Synuclein PATHO ELISA which utilizes the anti-human α-Synuclein 5G4 monoclonal antibody which strongly binds to the high molecular weight fraction of β-sheet rich oligomers, making it a promising tool in the research of Parkinson’s disease.
- TDP43 accumulated in the cytoplasm is characteristic of cytoplamsmic inclusions observed in ALS and in many cases of frontotemporal lobar degeneration (FTLD).
CSF samples have disadvantages and are not always available so it is useful to measure certain biomarkers in blood. The new Tecan Neuro-IP product portfolio, provided by Roboscreen, is a breakthrough in the pretreament of blood and CSF samples. The use of immunoprecipitation eliminates inhibiting matrix effects and enriches the target protein. Analysis of the sample is then possible using a variety of assay systems such as the Roche Elecsys®, the Mesoscale QuickPlex, Quanterix SIMOA®, Fujirebio Lumipulse®, and any type of ELISA.
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BioVendor R&D product range for neural tissue markers includes a variety of ELISA kits, antibodies and purified proteins for research in the field of neurodegenerative diseases. A full list of the product available can be found on the BioVendor website.
The product portfolio from Mediagnost includes the ELISA kit for the quantitative detection of Progranulin.
Progranulin has an application in the field of neurological research as an established marker for frontotemporal dementia (FTD). Decreased serum progranulin concentrations occur in approximately 5-10% of patients with FTD.