Neurology

Neurology

Laboratory reagents to aid the diagnosis and monitoring of neurodegenerative diseases.

Neurodegenerative Diseases

Neurodegenerative diseases are a group of disorders that are characterised by the progressive loss of structure respective function of neurons, including their death. The most known disorders include Alzheimer’s Disease, Parkinson’s disease, Multiple Sclerosis and Amyotrophic Lateral Sclerosis (ALS), but as research in this field increases, more diseases are shown to have similar cellular and sub-cellular pathogenic mechanisms.

Oxford Biosystems offers a range of products to detect and measure neurodegeneration biomarkers in both cerebrospinal fluid and blood samples.

IBL International GmbH, part of the Tecan Group, have wide range of ELISA products for research in the field of neurodegeneration:

CSF samples have disadvantages and are not always available so it is useful to measure certain biomarkers in blood. The new Tecan Neuro-IP product portfolio, provided by Roboscreen, is a breakthrough in the pretreament of blood and CSF samples. The use of immunoprecipitation eliminates inhibiting matrix effects and enriches the target protein. Analysis of the sample is then possible using a variety of assay systems such as the Roche Elecsys®, the Mesoscale QuickPlex, Quanterix SIMOA®, Fujirebio Lumipulse®, and any type of ELISA.

Contact us for more information.


BioVendor R&D product range for neural tissue markers includes a variety of ELISA kits, antibodies and purified proteins for research in the field of neurodegenerative diseases. A full list of the product available can be found on the BioVendor website.


The product portfolio from Mediagnost includes the ELISA kit for the quantitative detection of Progranulin.

Progranulin has an application in the field of neurological research as an established marker for frontotemporal dementia (FTD). Decreased serum progranulin concentrations occur in approximately 5-10% of patients with FTD.


Apolipoprotein E in Neurodegenerative disease

Apolipoprotein E (ApoE) has key roles in the transport of cholesterol and other lipids within blood circulation and the central nervous system. ApoE is polymorphic exhibiting three different alleles, which differ by an alternating combination of two amino acids at position 112 and 158: E2 (C112_C158), E3 (C112_R158) and E4 (R112_R158).

Certain variants of Apolipoprotein E (ApoE) have been linked to specific health conditions: ApoE2 is associated with type III hyperlipoproteinemia, while ApoE4 is associated with cardiovascular disease and Alzheimer’s disease.


The ViennaLab Apo E StripAssay® is an assay for the identification of apolipoprotein (apo) E isoforms E2, E3 and E4 based on polymerase chain reaction (PCR) and reverse-hybridization. The assay allows the discrimination between six possible heterozygous or homozygous apo E genotypes: E2/2, E2/3, E2/4, E3/3, E3/4, E4/4.


Kamiya Biomedical Company provides reagents for the quantitative determination of human Apolipoprotein E (Apo E) in serum and plasma by immunoturbidimetric assay. Protocols are available for use on a variety of different chemistry analysers.

Research into neurodegenerative diseases, diagnosis and treatment, is increasing rapidly and more information is becoming available. If you have a specific requirement for kits and reagents please contact us to discuss how we can help.


Elecsys® is a trademark of Roche Diagnostics GmbH.
SIMOA® is a trademark of Quanterix Corporation.
Lumipulse® is a trademark of Fujirebio Inc.

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