Cytogenetics
The chromosome content of a cell, called karyotype, is classified on the basis of both chromosome number and morphology, which are fixed characteristics for a particular species. The identification and characterisation of either constitutional or acquired chromosome abnormalities, are the focus of two large areas of diagnostic investigation. Cytogenetic analysis is a fundamental tool for prenatal and postnatal diagnosis of several pathologies (concerning general and specialist medicine), and it is the basis of prevention programmes regarding congenital and hereditary diseases.
EuroClone® has developed a perfect combination of media, plastic supports, synchronizing agents, and equipment for pre and postnatal cytogenetic analysis.
Chromosome Media enable simplified operative protocols and produce highly reproducible and readable specimens for microscopic examination. The number of metaphases and chromosome quality are superior compared to conventional media.
- Chromosome M
Chromosome Medium M is a complete medium for bone marrow cultures and is supplied in bottles or ready to use culture tubes.
- Chromosome P
Chromosome Medium P is a complete medium for peripheral blood cultures and is supplied in bottles (100ml or 500ml) or ready to use culture tubes.
- SynchroSet
Synchroset consists of two solutions, which added to the culture medium, and following an extremely simple protocol, allow the synchronization of the cell cycle in both lymphocytes and bone marrow cells. Synchroset is suitable for the production of high numbers of prometaphases in which the chromosomes are appropriate for high resolution banding techniques (up to 850-1000 bands per haploid set). This methodology is suitable for more precise identification of breakpoints and minor abnormalities which often cause severe plurimalformative conditions.
- ChromoLymphoB Proliferation MIX
The analysis of chromosomal aberrations of neoplastic cells in patients with haematological disorders provides significant diagnostic and prognostic information. ChromoLympho-B Proliferation MIX, is the mix of ChromoLypmho B Factor and Interleukin 2. ChromoLypmho B Factor is a “new generation” proliferation reagent that, when used in vitro in cultured peripheral blood/bone marrow cells from patients affected with chronic lymphocytic leukaemia (CLL) and other B-cell lymphoproliferative syndromes, has proved a very high success rate of metaphase analysis and an impressive abnormality rate similar to FISH analysis findings.