Oxford Biosystems has a comprehensive range of ELISA kits for the detection and quantification of a wide variety of immune-modulators including cytokines, chemokines, cell adhesion molecules and apoptosis markers.
We also supply ELISA kits for the measurement of specific antibody response to vaccination. These assays are based on the detection of specific IgG and total antibodies (TAb) in serum and plasma and are calibrated against WHO standards where available. The assays are intended for use in the assessment and monitoring of immunisation status and epidemiological studies.
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HMGB1 has increasingly attracted the attention of researchers and has become one of the most intriguing molecules within the complete arsenal of proteins of the innate immune system. It is present in the nucleus and cytoplasm of mammalian cells and is involved in gene transcription as a chromatin binder. It can be released passively as a soluble molecule from necrotic cells or may be actively secreted from inflammatory cells, thus it acts like a cytokine with similar pro-inflammatory effects to TNF-alpha and IL-6.
HMGB1 is therefore involved with any diseases coping with dying necrotic cells, examples include, sepsis and septic shock, stroke, cancer and viral infections. There are over 2,000 scientific articles published regarding HGMB1, with over 100 of these having used the IBL HMGB1 ELISA.
IBL International’s HMGB1 ELISA, which has been developed by Shino-Test Corporation, Japan, in cooperation with Prof. Dr. Ikuro Maruyama, Kagoshima University, is the worldwide renowned assay to quantify HMGB1 in any experimental setting.