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HE4

This marker in combination with CA 125 improves the decision making for determining if it is a pelvic mass or ovarian cancer. The FDA has now cleared HE4 to determine the likelihood of ovarian cancer in women who represent with adnexal mass.

Fujirebio news release

The kit is manufactured by Fujirebio and is available in the ELISA format. Fujirebio have a dedicated HE4 website which includes:

• Further information about HE4 and CA125
• A selection of clinical studies
• Risk of Ovarian Malignancy Algorithm (ROMA)

We also have an edition detailing some important HE4 studies on our Crosslinks page.

TIMP-1

TIMP-1 is one of the key inhibitors of Matrix Metalloproteinases. Recently it has been implicated in inhibition of programmed cell death apoptosis and accordingly, a number of publications have shown a highly significant association between high plasma TIMP-1 levels and poor prognosis in patients suffering from colorectal cancer. An ELISA kit for human application is available.

TIMP Brochure

Chromogranin A

Chromogranin A is a 49 kDa acidic protein that consists of 439 amino acids encoded on chromosome 14. Chromogranin A has been identified in a number of normal and neoplastic endocrine tissues. It was demonstrated that an elevated circulating chromogranin A level would be a marker of tumors of neuroendocrine origin. However, the most significant clinical use of chromogranin A is related to the diagnostic procedure in patients of pheochromocytoma.

In addition, chromogranin A may be used for the diagnosis of endocrine tumors that do not produce their specific hormones, for example, calcitonin negative but chromogranin A positive C-cell carcinoma; zero-cell carcinoma; beta-cell carcinoma; parathyroid carcinoma. ELISA and RIA kits are available from a number of different suppliers.